Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection
نویسندگان
چکیده
منابع مشابه
Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection.
Among infectious agents, measles virus (MV) remains a scourge responsible for 1 million deaths per year and is a leading cause of childhood deaths in developing countries. Although MV infection itself is not commonly lethal, MV-induced suppression of the immune system results in a greatly increased susceptibility to opportunistic bacterial infections that are largely responsible for the morbidi...
متن کاملMeasles Virus Infection: Mechanisms of Immune Suppression
Measles virus (MV) is a highly contagious respiratory pathogen that causes systemic disease; most individuals recover with lifelong immunity to MV. Enormous progress toward measles elimination has been made worldwide, in large part due to the availability of a safe and effective vaccine (CDC, 2000; WHO, 2005; 2009; 2010). However, measles infections still cause 500,000 deaths annually, mostly d...
متن کاملFailure of innate and adaptive immune responses in controlling hepatitis C virus infection.
Effective innate and adaptive immune responses are essential for the control of hepatitis C virus (HCV) infection. Indeed, elimination of HCV during acute infection correlates with an early induction of innate and a delayed induction of adaptive immune responses. However, in the majority of acutely HCV-infected individuals, these responses are insufficient to clear the virus and persistence dev...
متن کاملEarly kinetics of innate and adaptive immune responses during hepatitis B virus infection.
BACKGROUND AND AIMS Innate immunity appears to be silent in acutely hepatitis B virus (HBV)-infected chimpanzees, as shown by microarray analysis of intrahepatic gene expression. Whether this observation also applies to HBV pathogenesis in man remains undefined. The aim of this study was thus to characterise natural killer (NK) and CD56(+) natural T (NT) cell responses early after human HBV inf...
متن کاملInnate immune responses against Epstein Barr virus infection.
EBV persists life-long in >95% of the human adult population. Whereas it is perfectly immune-controlled in most infected individuals, a minority develops EBV-associated diseases, primarily malignancies of B cell and epithelial cell origin. In recent years, it has become apparent that the course of primary infection determines part of the risk to develop EBV-associated diseases. Particularly, th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2003
ISSN: 0021-9738
DOI: 10.1172/jci200313603